Polymer-mediated cryopreservation of bacteriophages

Dendrimers in dilute solution with asymmetry of branching were simulated by the Brownian dynamics method. In this simulation a coarse-grained dendrimer model and athermal solvent conditions implemented, extending previous work to wider range branch asymmetries at fixed average spacer lengths high generation numbers close theoretical limit. We considered both global local structural characteristics dendrimers. The ones, such as distance ends from center, radius gyration, hydrodynamic shape anisotropy, are practically insensitive branching. effect is revealed mainly structure particular radial density profile changes its convex concave one an increase asymmetry. As compared symmetrical case, distribution terminal monomer units asymmetrical dendrimers shifts towards periphery. monomers on denser environment their analogs. shorter spacers less stretched more turned back core than longer ones located same topological simulations also demonstrated that leads smaller overlap dendron fragments inside case. However, total was found be independent